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[目的]探讨肝上皮样血管内皮瘤(HEHE)的临床特点。[方法]收集5例HEHE患者的住院资料并随访,结合文献进行临床分析研究。[结果]男性4例,女性1例,均表现为肝多发肿块,经肝穿刺活检行常规病理和免疫组化检查确诊。肿瘤细胞多呈条索状或簇状排列,腺样分布,浸润性生长,可见胞质内空腔形成,腔内偶可见单个红细胞,胞质嗜酸,免疫组化检测肿瘤细胞CD34、CD31、FⅧ阳性。[结论]HEHE病理特征表现为肿瘤由具有上皮样或组织细胞样形态特征的内皮细胞组成。临床症状不典型,需病理检查确诊。治疗宜采取手术为主的综合治疗,预后较好。
[Objective] To investigate the clinical features of hepatic epithelioid hemangioendothelioma (HEHE). [Methods] The hospitalization data of 5 patients with HEHE were collected and followed up, and the clinical data were analyzed. [Results] There were 4 males and 1 females. All of them showed multiple lumps of liver and were diagnosed by routine biopsy and immunohistochemistry after liver biopsy. Tumor cells were mostly cord-like or clustered arrangement, adenoid distribution, invasive growth, visible cytoplasmic cavity formation, the cavity can be seen even single red blood cells, cytoplasmic acidosis, immunohistochemical detection of tumor cells CD34, CD31, F Ⅷ positive. [Conclusion] The pathological features of HEHE are that the tumor consists of endothelial cells with epithelial-like or tissue-like morphological features. Clinical symptoms are not typical, required pathological examination confirmed. The treatment should be based on the comprehensive treatment of surgery, the prognosis is good.