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[目的]了解Hsp90及ILK在胃癌组织中的表达情况,并探讨其相关临床意义。[方法]用免疫组化EnVisionⅠ法对胃癌组40例、慢性萎缩性胃炎伴不典型增生组20例、浅表性胃炎组20例进行免疫组化染色,分析二者在3组中表达、相关性及其与胃癌病理参数的关系。[结果]Hsp90和ILK在胃癌组中显著高于其他组(P<0.05),在慢性萎缩性胃炎伴不典型增生组及浅表性胃炎组中呈低表达或不表达,这2组间表达差异无统计学意义(P>0.05)。Hsp90与ILK表达呈显著正相关。ILK的高表达与Borrmann分型、淋巴结转移和临床分期显著相关,而Hsp90未显示与胃癌临床病理参数有明显相关。[结论]Hsp90和ILK在胃癌组织中的表达具有特异性,且ILK的表达与胃癌进展有关,提示两者均是胃癌化学治疗的潜在靶位。
[Objective] To understand the expression of Hsp90 and ILK in gastric cancer tissues and explore their related clinical significance. [Methods] 40 cases of gastric cancer group, 20 cases of chronic atrophic gastritis with dysplasia, and 20 cases of superficial gastritis were immunohistochemically stained by EnVision I immunohistochemical method. The expression and correlation between the two groups were analyzed. Sex and its relationship with pathological parameters of gastric cancer. [Results] Hsp90 and ILK were significantly higher in gastric cancer group than in other groups (P<0.05). They were low or no expression in chronic atrophic gastritis with atypical hyperplasia group and superficial gastritis group. The difference was not statistically significant (P>0.05). There was a significant positive correlation between Hsp90 and ILK expression. The high expression of ILK was significantly associated with Borrmann type, lymph node metastasis, and clinical stage. Hsp90 did not show significant correlation with clinicopathological parameters of gastric cancer. [Conclusion] The expression of Hsp90 and ILK in gastric cancer tissues is specific, and the expression of ILK is related to the progress of gastric cancer, suggesting that both are potential targets for the chemotherapy of gastric cancer.