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三甲氧啉[4-(3,4,5三甲氧基苯甲酰基)吗啡啉,4-(3,4,5-trimethoxybenzoyl)morpholine trioxazine]和甲氧啉[4-(4-甲氧基苯甲酰基)吗啡啉,4-(4-methoxybenzoyl)morpholine]均为吗啡啉类化合物。资料表明,三甲氧啉是一种高效低毒的安定药,适用于伴有恐惧、紧张和情动激动的神经精神症状、儿童行为障碍,也可用于清除神经质症状群患者的精神兴奋,在精神病的治疗上可作为维持用药,甲氧啉则尚未见用于临床。为了阐明国产三甲氧啉及其同类药甲氧啉的主要药理作用和毒性,我们就下列指标对两药进行了初步的对比性研究。1.对戊巴比妥钠阈下催眠剂量的影响:实验按随机区组法分三组进行。各组分别 ip 蒸馏水、等分子剂量的甲氧啉(80mg/kg)或三甲氧啉(101.7mg/kg),20分钟
Trimethoxy- [4- (3,4,5-trimethoxybenzoyl) morpholine, 4- (3,4,5-trimethoxybenzoyl) morpholine trioxazine] and methoxyphenol Formyl) morpholine, 4- (4-methoxybenzoyl) morpholine] are all morpholine compounds. Data show that trimethophenone is a highly efficient and low toxicity of diazepam for fear, tension and emotion agile neuropsychiatric symptoms, children’s behavioral disorders, can also be used to clear the nervous excitement patients with mental disorders, in psychosis The treatment can be used as maintenance medication, methionine has not been seen for clinical use. In order to elucidate the major pharmacological effects and toxicity of domestic trimethoprim and its methylamine, we conducted a preliminary comparative study of the two drugs against the following indices. 1. The impact of subthreshold hypnosis dose of pentobarbital sodium: The experiment was divided into three groups according to random block method. Each group was ip distilled water, an equal molecular dose of methoxine (80mg / kg) or trimethylamine (101.7mg / kg) for 20 minutes