目的观察复方丹参注射液联合维生素E及钙制剂治疗妊娠期高血压疾病的临床疗效及对妊娠结局的影响,以便改善妊娠期高血压疾病患者妊娠结局。方法选择2014年6月-2016年12月常山县妇幼保健院收治的轻、中度妊娠期高血压疾病患者200例作为研究对象,按照就诊顺序编号,采用数字随机表法将患者随机分为对照组和观察组,每组100例。对照组按照《妊娠期高血压疾病诊治指南(2012版)》建议的常规治疗方案进行治疗,观察组在对照组常规治疗基础上,再加用复方丹参注射液+维生素E+钙制剂治疗,两组患者均治疗4周,比较两组患者完成疗程后临床症状(头痛、眼花、胸闷、上腹部不适、疼痛、消化系统症状)改善情况和相关实验室指标(平均动脉压、尿蛋白)改善情况。比较两组孕妇观察期内的母儿妊娠结局(妊娠期高血压疾病严重程度分级不变或增加、子痫、红斑狼疮、终止妊娠例数、胎儿宫内窘迫、低体质量儿、新生儿窒息、死亡)。结果两组患者完成治疗疗程后,临床症状均较治疗前有明显改善,但观察组患者改善率明显高于对照组,差异均有统计学意义(均P<0.05);两组患者收缩压、尿蛋白均较治疗前有明显降低,但观察组降低程度明显高于对照组,差异均有统计学意义(均P<0.05);妊娠期内观察组孕妇出现子痫、妊娠期高血压疾病严重程度分级不变或增加、终止妊娠的几率均明显低于对照组,差异均有统计学意义(均P<0.05);胎儿宫内窘迫、低体质量儿、新生儿窒息率均明显低于对照组患者,差异均有统计学意义(均P<0.05)。结论复方丹参+维生素E+钙制剂辅助治疗妊娠期高血压疾病,可有效改善患者临床症状,控制血压,提升母儿预后,对患妊娠期高血压疾病患者具有重要的临床价值。 Objective To observe the clinical efficacy of Compound Salvia Miltiorrhiza Injection combined with Vitamin E and Calcium in the treatment of hypertensive disorder complicating pregnancy and its effect on pregnancy outcome so as to improve the pregnancy outcome in patients with hypertensive disorders during pregnancy. Methods 200 patients with mild and moderate gestational hypertension admitted to Changshan County Maternal and Child Health Hospital from June 2014 to December 2016 were selected as research objects and were randomly divided into control Group and observation group, 100 cases in each group. The control group was treated according to the routine treatment plan recommended by the Guideline for Diagnosis and Treatment of Hypertensive Disorder Complicated in Pregnancy (Version 2012). The observation group was treated with the compound Danshen injection + vitamin E + calcium preparation on the basis of routine treatment in the control group. The two groups The patients were treated for 4 weeks. The improvement of clinical symptoms (headache, vertigo, chest tightness, upper abdominal discomfort, pain, digestive symptoms) and related laboratory parameters (mean arterial pressure and urinary protein) after the completion of treatment were compared between the two groups. The results of maternal and fetal pregnancy were compared between the two groups during the observation period (the grading of the severity of hypertensive disorder complicating pregnancy was unchanged or increased, the number of cases of eclampsia, lupus erythematosus, termination of pregnancy, fetal distress, low birth weight, neonatal asphyxia ,death). Results The clinical symptoms of both groups were significantly improved after treatment, but the improvement rate in the observation group was significantly higher than that in the control group (all P <0.05). The systolic blood pressure, Urinary protein were significantly lower than before treatment, but the observation group decreased significantly higher than the control group, the differences were statistically significant (both P <0.05); pregnant women in the observation group during pregnancy eclampsia, severe hypertensive disorders of pregnancy The degree of grading unchanged or increased, the probability of termination of pregnancy were significantly lower than the control group, the difference was statistically significant (both P <0.05); fetal distress, low birth weight children, neonatal asphyxia were significantly lower than the control Group patients, the differences were statistically significant (all P <0.05). Conclusion Compound Salviae + vitamin E + calcium preparations in the treatment of gestational hypertension can effectively improve the clinical symptoms, control blood pressure and improve the prognosis of pregnant women. It has important clinical value for patients with hypertensive disorder complicating pregnancy.