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将ＥＢ病毒感染的人胎儿鼻咽粘膜移植于２２只Ｂａｌｂ／ｃ裸鼠皮下，每周一次皮下注射丁酸和佛波醇二酯（ＴＰＡ）。约１０天后肿物逐渐增大，１５周内行病理学检查，诊断为恶性淋巴瘤４例（其中Ｔ淋巴细胞型３例），未分化癌３例。ＰＣＲ和原位杂交显示，两种肿瘤组织和细胞中均含有ＥＢ病毒ＬＭＰ１基因，核苷酸序列分析表明，与Ｂ９５一８细胞ＬＭＰ１基因相应序列的同源性约为９６％和９９％。说明ＥＢ病毒感染人胎儿新鲜鼻咽上皮细胞和淋巴细胞，引起细胞恶性转化后，ＥＢ病毒ＤＮＡ仍存在于癌细胞中。本研究在国际上首次证明，完整的ＥＢ病毒和促癌物协同作用可以诱发未分化癌。
The EB virus-infected human fetal nasopharyngeal mucosa was transplanted subcutaneously in 22 Balb / c nude mice and the mice were injected subcutaneously with butyrate and phorbol diester (TPA) once a week. About 10 days after the tumor gradually increased, 15 weeks pathological examination, diagnosis of malignant lymphoma in 4 cases (including 3 cases of T lymphocyte type), undifferentiated carcinoma in 3 cases. PCR and in situ hybridization showed that the Epstein-Barr virus LMP1 gene was contained in both tumor tissues and cells. Nucleotide sequence analysis showed that the homology of LMP1 gene was 96% and 99% with that of B95-8 cells. EB virus infection in human nasopharyngeal epithelial cells and lymphocytes, causing malignant transformation of cells, Epstein-Barr virus DNA is still present in cancer cells. This study for the first time in the world proves that the complete synergism of Epstein-Barr virus and carcinogen can induce undifferentiated carcinoma.