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目的探讨乳腺癌组织内淋巴管密度(LVD)与血管内皮生长因子受体-3(VEGFR-3)的相关性。方法收集衡水市哈励逊国际和平医院2006-2009年乳腺癌患者标本40例,10例正常乳腺组织标本;采用酶组织化学双重染色法,对上述标本的LVD进行检测。同时采用免疫组化SP法检测VEGFR-3的表达。结果乳腺癌组织的LVD、VEGFR-3表达明显高于对照组。乳腺癌淋巴结转移阳性组LVD、VEGFR-3表达明显高于阴性组。结论乳腺癌组织中LVD与VEGFR-3的表达促进乳腺癌淋巴结的转移。
Objective To investigate the relationship between lymphatic vessel density (LVD) and vascular endothelial growth factor receptor-3 (VEGFR-3) in breast cancer. Methods Forty breast cancer patients from 2006 to 2009 in Hailun International Peace Hospital of Hengshui City were collected, and 10 cases of normal breast tissue samples were collected. The LVD of these samples was detected by enzyme histochemical double staining. Immunohistochemical SP method was used to detect the expression of VEGFR-3. Results The expression of LVD and VEGFR-3 in breast cancer tissues was significantly higher than that in the control group. The expression of LVD and VEGFR-3 in lymph node metastasis positive group was significantly higher than that in negative group. Conclusion The expression of LVD and VEGFR-3 in breast cancer tissue promotes the metastasis of breast cancer lymph nodes.