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目的探讨CD64指数和降钙素原(PCT)对恶性血液病合并细菌感染的早期诊断价值。方法选取2014年1月-2017年5月收治的恶性血液病患者作为研究对象,其中感染组86例,非感染组78例,感染组又分为革兰阴性菌感染组和革兰阳性菌感染组,选取同一时期健康体检者100例作为对照组,比较分析各组患者CD64和PCT水平变化,并就CD64和PCT对恶性血液病合并细菌感染的诊断效能和相关性进行分析。结果革兰阴性菌感染组CD64和PCT水平明显高于革兰阳性菌感染组;感染组CD64和PCT水平较对照组和非感染组均明显升高,经治疗后CD64和PCT水平均显著下降;感染组CD64和PCT的阳性率显著高于对照组和非感染组,以上差异均有统计学意义(P<0.05)。相关性分析表明,CD64和PCT之间呈正相关(r=0.816,P<0.01)。结论 CD64和PCT能够作为恶性血液病合并细菌感染的诊断指标,对细菌感染的早期诊断与治疗具有重要的临床意义。
Objective To investigate the early diagnostic value of CD64 index and procalcitonin (PCT) in patients with hematological malignancies complicated with bacterial infection. Methods From January 2014 to May 2017, patients with hematologic malignancies were selected as study subjects, including 86 cases of infection and 78 cases of non-infection, the infection was divided into gram-negative bacteria infection and gram-positive bacteria infection Group. 100 healthy subjects were selected as the control group during the same period. The changes of CD64 and PCT levels in each group were compared. The diagnostic efficacy and correlation between CD64 and PCT in patients with hematological malignancies complicated by bacterial infection were analyzed. Results The levels of CD64 and PCT in Gram-negative bacteria group were significantly higher than those in Gram-positive bacteria group. The levels of CD64 and PCT in infected group were significantly higher than those in control group and non-infected group, and the levels of CD64 and PCT decreased significantly after treatment. The positive rates of CD64 and PCT in the infected group were significantly higher than those in the control group and non-infected group, the differences were statistically significant (P <0.05). Correlation analysis showed that there was a positive correlation between CD64 and PCT (r = 0.816, P <0.01). Conclusion CD64 and PCT can be used as diagnostic indicators of bacterial infection in patients with hematological malignancies. It has important clinical significance for the early diagnosis and treatment of bacterial infections.