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目的:调查通过献血途径感染人类免疫缺陷病毒(HIV)的203例患者的情绪状况及生活质量。方法:采用贝克抑郁问卷、复合性国际诊断用检查提纲和SF-36对203例通过献血途径感染HIV的患者(HIV阳性组)及年龄、性别和受教育年限相匹配的198例HIV阴性献血者进行调查。结果:①HIV阳性组献血次数多于HIV阴性组(52.2±95.4/13.2±23.9,P<0.001),已婚者少于HIV阴性组(88.6%/ 95.5%,P=0.020),丧偶者多于HIV阴性组(10.9%/4.5%,P=0.020),失业率高于HIV阴性组(21.7%/4.0%,P<0.001),前一年全年工作时间少于HIV阴性组(5.0±3.5/7.5±3.0,P<0.001),家庭月收入低于HIV阴性组(476.3±412.7/709.9±513.7,P<0.001)。②HIV阳性组被诊断为获得性免疫缺陷综合征(AIDS)者占56.6%。HIV阳性组抑郁症的终生患病率为13.8%,HIV阴性组的终生患病率为5.1%。HIV阳性组的抑郁总分(11.3±11.3/6.6±9.6)、躯体(3.3±2.9/2.0±2.6)和非躯体因子分(8.0±8.8/4.6±7.4)均高于HIV阴性组(P<0.001)。HIV阳性组达轻度抑郁以上者占40.4%。HIV阳性组已制定自杀计划者高于HIV阴性组(8.4%/3.0%,P<0.05)。HIV阳性组总体生理健康(48.3±9.7/ 55.5±7.0)和心理健康(48.8±8.9/55.1±7.8)得分均低于HIV阴性组(P<0.001)。③HIV阳性组的贝克抑郁问卷总分与T细胞亚群CD4细胞计数无显著相关,与总体生理健康及心理健康呈显著负相关(r=- 0.46～0.68,P<0.001)。结论:HIV阳性患者生存状况较差。对HIV阳性感染者而言,抑郁给患者生活质量造成全面的影响,抑郁和自杀风险仍然是需要干预和处理的问题。
Objective: To investigate the emotional status and quality of life of 203 patients infected with human immunodeficiency virus (HIV) through blood donation. METHODS: A total of 198 HIV-negative donors matched for age, sex and length of education were enrolled in this study using Beck’s Depression Questionnaire, composite international diagnostic syllabus and SF-36 in 203 HIV-infected patients (HIV-positive) Investigate. Results: ①The number of blood donation in HIV positive group was more than that in HIV negative group (52.2 ± 95.4 / 13.2 ± 23.9, P <0.001), less married than HIV negative group (88.6% / 95.5%, P = 0.020) (10.9% / 4.5%, P = 0.020). The unemployment rate was higher in HIV-negative patients than in HIV-negative patients (21.7% / 4.0%, P <0.001) /7.5 ± 3.0, P <0.001). The monthly family income was lower than that of HIV-negative group (476.3 ± 412.7 / 709.9 ± 513.7, P <0.001). ②HIV positive group was diagnosed as acquired immunodeficiency syndrome (AIDS) accounted for 56.6%. The lifetime prevalence of HIV-positive depression was 13.8% and the lifetime prevalence of HIV-negative patients was 5.1%. The total score of depression (11.3 ± 11.3 / 6.6 ± 9.6), body (3.3 ± 2.9 / 2.0 ± 2.6) and non-body factor (8.0 ± 8.8 / 4.6 ± 7.4) in HIV positive group were higher than those in HIV negative group (P < 0.001). HIV-positive group accounted for 40.4% of mild depression. HIV positive group suicide plan has been developed over the negative group (8.4% / 3.0%, P <0.05). The scores of overall physical health (48.3 ± 9.7 / 55.5 ± 7.0) and mental health (48.8 ± 8.9 / 55.1 ± 7.8) in HIV positive group were lower than those in HIV negative group (P <0.001). (3) The total score of Baker depression questionnaire in HIV positive group was not significantly correlated with CD4 cell count of T cell subsets, but negatively correlated with overall physical and mental health (r = - 0.46-0.68, P <0.001). Conclusion: The survival of HIV-positive patients is poor. For HIV-positive people, depression has an overall impact on the quality of life of patients, and the risks of depression and suicide remain issues that need intervention and management.