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目的分析阿托伐他汀对高血压前期伴高脂血症患者颈动脉粥样硬化的影响。方法 80例高血压前期伴高脂血症患者,随机分为观察组和对照组,各40例。两组患者每天给予75 mg的肠溶阿司匹林,观察组患者在此基础上给予阿托他汀10 mg/d,观察治疗前和治疗6个月后的血压、血脂、颈动脉斑块。结果治疗后观察组收缩压(SBP)、舒张压(DBP)均优于对照组(P<0.05)。观察组患者总胆固醇(TC)、低密度的脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后斑块个数减少,斑块厚度变薄,与对照组相比差异有统计学意义(P<0.05),观察组患者的硬斑块转变率高于对照组,差异有统计学意义(P<0.05)。结论阿托伐他汀能够有效调节血脂水平,降低血浆中的LDL-C、TG、TC水平,减缓动脉粥样硬化。
Objective To analyze the effect of atorvastatin on carotid atherosclerosis in patients with prehypertension and hyperlipidemia. Methods Eighty patients with prehypertension and hyperlipidemia were randomly divided into observation group and control group, 40 cases in each. Patients in both groups were given 75 mg enteric-coated aspirin daily, and patients in the observation group were given atorvastatin 10 mg / d. Blood pressure, blood lipids and carotid plaques were observed before and 6 months after treatment. Results After treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the observation group were better than those of the control group (P <0.05). The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) in the observation group were lower than those in the control group, with statistical significance (P <0.05). In the observation group, the number of plaque decreased and the thickness of plaque became thinner, the difference was statistically significant compared with the control group (P <0.05). The change rate of the hard plaque in the observation group was higher than that of the control group Significance (P <0.05). Conclusions Atorvastatin can effectively regulate blood lipids, reduce the levels of LDL-C, TG and TC in plasma, and attenuate atherosclerosis.