作者总结两侧听神经瘤12例,以一侧听神经瘤6例为对照,讨论临床所见及组织学表现。两侧听神经瘤的组织学表现:HE染色,肿瘤细胞呈椭圆形或纺锤形,细胞质细长波浪状嗜酸性。12例中有6例瘤细胞呈栅状排列,S-100蛋白染色大部分瘤细胞呈阳性者11例,12例中有2例瘤组织内可见涡状构造物,形成该构造的细胞S-100蛋白染色阳性。1例可见神经节细胞。临床表现:例1至例9家族史、皮下肿瘤及皮肤母斑(Cafe′au lait斑)3项中至少2 The authors summarized 12 cases of bilateral acoustic neuroma and 6 cases of acoustic neuroma as a control to discuss clinical findings and histological findings. The histological appearance of the acoustic neuromas on both sides: HE staining, the tumor cells are oval or spindle-shaped, and the cytoplasm is elongated and wavy and eosinophilic. Six of the 12 cases had a grid-like arrangement of tumor cells, 11 of which were stained positive for S-100 protein in most of the tumor cells, and 2 of 12 cases had swirling structures in the tumor tissue, forming cells of this structure S- 100 protein staining positive. One case showed ganglion cells. Clinical manifestations: Family history of cases 1 to 9, subcutaneous tumors, and at least 2 of 3 skin lesions (Cafe’au lait plaques)