论文部分内容阅读
目的观察去甲肾上腺素并多巴酚丁胺治疗脓毒性休克对肾脏作用的影响。方法我院ICU符合脓毒性休克的48例病人随机分为两组,A组给于去甲肾上腺素并多巴酚丁胺,B组给于大剂量多巴胺并多巴酚丁胺,观察治疗前和治疗后24h平均动脉压(MAP)、心率(HR)、尿量、血尿素氮(BUN)、肌酐(CRE)及尿β2微球蛋白(Uβ2-MG)变化。结果治疗24h后,A组平均动脉压上升,心率下降,尿量增加,血BUN,CRE,Uβ2-MG均较治疗前有所恢复。结论在脓毒性休克的治疗中,在充分容量复苏的基础上给于去甲肾上腺素并多巴酚丁胺等血管活性药物可以改善肾功能。
Objective To observe the effects of norepinephrine and dobutamine on renal function in septic shock. Methods 48 patients with septic shock in our hospital were randomly divided into two groups. Group A was given norepinephrine and dobutamine. Group B was given high dose dopamine and dobutamine. Before treatment, (MAP), heart rate (HR), urine output, blood urea nitrogen (BUN), creatinine (creatinine) and urine β2 microglobulin (Uβ2-MG) Results After treatment for 24 hours, mean arterial pressure increased, heart rate decreased, urine output increased, blood BUN, CRE and Uβ2-MG in group A recovered compared with those before treatment. Conclusions In the treatment of septic shock, vasoactive drugs such as norepinephrine and dobutamine can improve renal function on the basis of adequate volume recovery.