Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandr

来源 :中国天然药物 | 被引量 : 0次 | 上传用户:zhuanzhiboke
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Nineteen preschisanartane-type schinortriterpenoids (SNTs),among which eleven ones were previously undescribed,were isolated from two Schisandra species,S.sphaerandra and S.rubriflora.Their structures were determined using 1D and 2D NMR spectroscopic analyses,NMR data comparison,quantum chemical calculation of NMR parameters,electronic circular dichroism (ECD),X-ray single crystal diffraction,and chemical derivation.Furthermore,structural re-examination of a few previously reported preschisanartane-type SNTs led to the structural revision of preschisanartanin J.Besides,it is suggested that the reported structures of arisanlactone D and schilancidilactone W should be re-checked.Finally,a few isolated SNTs were found to possess neurite outgrowthpromoting activities,and protective activities against neural injuries.
其他文献
A new sesquiterpenoid and two pregnane steroids,named vemobockolide C (1) and vernobockones A and B (2 and 3),respevtively,along with a known sesquiterpenoid,7,10-epoxy-ll-hydroxy-bisabol-2-en-15-al,were isolated from the aerial part of Vernonia bockiana.
The underground cane of Schizocapsa plantaginea (Hance) has long been used by Chinese ethnic minority as a constituent of anti-cancer formulae.Saponins are abundant secondary metabolic products located in the underground cane of this plant.The potential t
Stellera chamaejasme L.is a traditional Chinese medicine with a long history to treat stubborn skin ulcer,and it also has antiviral and antitumor effects.Neochamaejasmine B (NCB),Neochamaejasmine A (NCA) and Chamaechromone (CMC) are the major components i
Dendrobium officinale is not only an ornamental plant,but also a valuable medicinal herb that is widely used in traditional Chinese medicine.However,distinguishing D.officinale from other Dendrobium species is usually a difficult task.In this study,we dev
The present study was designed to improve storage stability and oral bioavailability of Ganneng dropping pills (GNDP)by transforming lignans of Herpetospermum caudigerum (HL) composed of herpetrione (HPE) and herpetin (HPN) into nanosuspension (HL-NS),the
Two new isomeric modified tripeptides,aspergillamides C and D (compounds 1 and 2),together with fifteen known compounds (compounds 3-17),were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.The structures of the new compound
Modified Da-chai-hu Decoction (MDD),a traditional Chinese medicinal formulation,which was empirically generated from Da-chai-hu decoction,has been utilized to treat severe acute pancreatitis (SAP) for decades.The aim of the present study was to explore it
Twenty-one lignans including three new ones (1,2 and 13) were isolated from Justicia procumbens.The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis.These compounds were evaluated for their cyt
Naodesheng (NDS) formula,which consists of Rhizoma Chuanxiong,Lobed Kudzuvine,Carthamus tinctorius,Radix Notoginseng,and Crataegus pinnatifida,is widely applied for the treatment of cardio/cerebrovascular ischemic diseases,ischemic stroke,and sequelae of
Two cyclopeptides,celogentin L (1) and its epimer lyciumin A (2) were firstly isolated from Celosia argentea L..The planar structures of the two compounds were fully determined by spectroscopic data,including 1D-,2D-NMR,and HR-ESI/MS.The absolute configur