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目的:以一对脑瘫—正常双生子的卵型鉴定与全面病因病证调查作基础,为集约地筛选形成脑瘫的主效基因作铺垫。方法:对脑瘫—正常双生子分别采用性状相似评分、指纹特征比较、血型、胎盘膜隔数和短串联重复序列(STR)等5种方法鉴别卵型。采用粗大运动功能评估(GMFM)、生活能力(ADL)、双生子四诊调查表、肾虚辨证因子、脑瘫脾肾两虚调查表等5个量表全面地评定病证特征。结果:脑瘫儿大双和正常儿小双为单卵双生子,大双GMFM和ADL评分分别为26、51·5;肾虚量表评分中脑瘫儿大双35分,正常儿小双7分;脾肾两虚量表大双肾虚评分为11分,脾虚分为14分,正常小双均为0分。讨论:对双生子卵型鉴定方法进行了全面应用分析,前瞻性的分析了以脑瘫—正常双生子为对象进行脑瘫证候分子生物学机制研究的优势。
OBJECTIVE: To lay foundation for the intensive screening of the major genes responsible for cerebral palsy, based on the investigation of the egg type of cerebral palsy-normal twin and the comprehensive etiology and pathogenesis. Methods: Five types of methods were used to identify the egg type of cerebral palsy - normal twin by similarity score, fingerprint characteristic comparison, blood type, placental septum number and short tandem repeat (STR). Five scales of gross motor function assessment (GMFM), viability (ADL), twin diagnostic questionnaire, syndrome differentiation of kidney deficiency and spleen-kidney deficiency syndrome of cerebral palsy were comprehensively evaluated. Results: Large double and normal children with cerebral palsy were single and twin twins. Large GMFM and ADL scores were 26 and 51 · 5, respectively. Spleen and kidney deficiency scale large kidney deficiency score was 11 points, spleen is divided into 14 points, the normal small double are 0 points. Discussion: A comprehensive application analysis of twins ovary type identification method, prospective analysis of the cerebral palsy - normal twins as the object for the study of molecular mechanisms of cerebral palsy advantage.