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目的探讨宫颈癌组织中CD44v7/8基因的异常表达及临床意义。方法1986～2000年沈阳医学院附属中心医院采用免疫组化的方法随机测定59例宫颈癌、18例尖锐湿疣和18例慢性宫颈炎组织中CD44v7/8基因的表达情况。结果宫颈癌、尖锐湿疣及慢性宫颈炎3种疾病中CD44v7/8表达阳性率分别为76.27%、11.11%和11.11%,宫颈癌组的CD44v7/8表达分别高于慢性宫颈炎组及尖锐湿疣组,且差异非常显著(P<0.01)。慢性宫颈炎组及尖锐湿疣组比较差异无显著性(P>0.05)。结论CD44v7/8蛋白的表达增强与宫颈癌的发生、发展及和局部浸润转移有关。
Objective To investigate the abnormal expression of CD44v7 / 8 gene in cervical cancer and its clinical significance. Methods The expression of CD44v7 / 8 gene in 59 cases of cervical cancer, 18 cases of condyloma acuminatum and 18 cases of chronic cervicitis was detected by immunohistochemistry in the Central Hospital of Shenyang Medical College from 1986 to 2000. Results The positive rates of CD44v7 / 8 in cervical cancer, condyloma acuminatum and chronic cervicitis were 76.27%, 11.11% and 11.11%, respectively. The expression of CD44v7 / 8 in cervical cancer was higher than that in chronic cervicitis and condyloma acuminatum , And the difference was significant (P <0.01). Chronic cervicitis group and genital warts no significant difference (P> 0.05). Conclusion The enhanced expression of CD44v7 / 8 protein is associated with the occurrence and development of cervical cancer and local invasion and metastasis.