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育龄妇女下丘脑性闭经引起的不孕症,在妇产科临床上是一种较为多见的疾病,其原因往往与黄体生成素释放激素(LHRH)分泌障碍有关。 人工合成的LHRH可以刺激脑垂体的促性腺细胞分泌黄体生成素,使卵巢卵泡正常发育,实验证明LHRH的生理释放是脉冲式的。其两次脉冲之间的间隔时间为80～116分钟,这种脉冲式的释放对保证垂体细胞对LHRH的敏感性有重要意义,因此需要一种专门的装置,将人工合成的LHRH按周期性方式,不间断的,小剂量地注入体内,以达最佳治疗效果。为此,重庆大学生物力学研究室王公瑞等与重庆医科大学一院妇产科毕婵琴等合作,研制成一种重量轻、体积小、携带方便、能定时定量自动注射药物的可携式微量注
Women of childbearing age hypothalamic amenorrhea caused by infertility in obstetrics and gynecology is a more common clinical disease, the reasons are often associated with the secretion of luteinizing hormone-releasing hormone (LHRH) disorders. Synthetic LHRH can stimulate the pituitary gonadotropin secretion of luteinizing hormone, the normal development of ovarian follicles, experiments show that LHRH physiological release is pulsed. The interval between two pulses is 80-116 minutes. This pulsed release is of great importance to ensure the sensitivity of pituitary cells to LHRH. Therefore, a special device is needed to separate the synthesized LHRH by periodicity Way, uninterrupted, small doses injected into the body, in order to achieve the best therapeutic effect. To this end, the Department of Biomechanics, Chongqing University, such as Wang Gongrui and Chongqing Medical University Hospital obstetrics and Gynecology Bishu Qin and other cooperation, developed a light weight, small size, easy to carry, regular quantitative auto-injection of portable micro-injection