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目的:研究疏毛吴茱萸醇提取物对家兔离体胃、肠平滑肌活动的影响。方法:采用家兔离体胃、肠平滑肌运动实验,观察疏毛吴茱萸醇提取物对家兔离体胃、肠平滑肌收缩活动的影响。结果:疏毛吴茱萸醇提取物低、中、高浓度(平滑肌槽内终浓度为0.001、0.0025、0.005g/mL)对家兔离体胃、肠平滑肌舒缩活动均有显著抑制作用,对氯化乙酰胆碱引起的胃、肠平滑肌兴奋有显著拮抗作用,与阿托品有协同作用,且呈剂量依赖性。结论:疏毛吴茱萸醇提取物对家兔胃、肠运动有显著抑制作用,其作用途径不仅与M胆碱受体有关,还可能与其他因素有关。
Objective: To study the effects of alcohol extract of Fructus Evodiae on the activities of isolated gastric and intestinal smooth muscle in rabbits. Methods: The gastric mucosa and intestinal smooth muscle of rabbits were used to study the effect of alcohol extract of Evodiamine on contractile activity of isolated gastric and intestinal smooth muscles in rabbits. RESULTS: Low, medium and high concentrations of Evodia rutaecarpa extract (0.001, 0.0025 and 0.005 g / mL in smooth muscle cells) significantly inhibited the contractile and contractile activities of isolated gastric and intestinal smooth muscles in rabbits. Acetylcholine caused by gastric, intestinal smooth muscle excited significant antagonism, and synergistic effect with atropine, and in a dose-dependent manner. Conclusion: The alcohol extract of Fructus Evodiae can significantly inhibit the gastric and intestinal motility in rabbits. The mechanism of its action is not only related to the M choline receptor, but also to other factors.