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脆性X综合征是最常见的遗传性精神发育迟缓的形式。有报道发病率在男性为1/1250,女性1/2500。可伴有多种表达和不完全的外显率。一般人群携带率的1/700新生儿。受累者淋巴细胞脆性位点在Xq27.3,它与FMR-1基因上的(CGG)_n序列过度复制
Fragile X syndrome is the most common form of hereditary mental retardation. It has been reported incidence of 1/1250 in men and 1/2500 in women. May be accompanied by a variety of expressions and incomplete penetrance. The general population carrying rate of 1/700 newborns. The affected lymphocyte fragile site is at Xq27.3, which is over-replicated with the (CGG) _n sequence on the FMR-1 gene