本文对藻酸双酯钠(PSS)和钙拮抗剂阿莫地平的肾血流动力学进行了对比研究。在活体去神经狗肾脏动脉注射PSS和阿莫地平,观察肾小球滤过率、肾血流、Na+、K+排泄率等9个肾动力指标。结果表明:PSS与阿莫地平均可明显促进肾血流,使尿量增加(P<0.01)。其它各肾血流动力学主要指标与阿莫地平相似但作用较弱,维持时间较短,显示较温和的特征,这对于扩展PSS的临床应用范围具有重要价值。 In this paper, the renal hemodynamics of sodium alginate (PSS) and calcium antagonist amodipine were compared. PSS and amodipine were injected into the renal artery of living denervated dogs, and the indexes of glomerular filtration rate, renal blood flow, Na + and K + excretion were observed. The results showed that both PSS and amodipine could significantly promote renal blood flow and increase urine output (P <0.01). Other major indicators of renal hemodynamics and amlodipine similar role but weak, short maintenance time, showing a more moderate features, which is of great value for the expansion of the clinical application of PSS.