近十年来,体外细胞培养中细胞分裂的调控问题受到重视。在细胞培养中,正常细胞的一些生长特点不同于肿瘤细胞者,这些差异反映了正常与肿瘤细胞的基本区别。正常细胞在长成为单层之前分裂快,但之后则分裂速度急剧下降而达所谓“饱和密度”。正常细胞的这种性质,可称之为“细胞分裂的密度依赖性调控”。在肿瘤细胞中无此现象。肿瘤细胞长成单层后仍然继续分裂,致使细胞 In recent ten years, the regulation of cell division in vitro cell culture has been taken seriously. In cell culture, some of the growth characteristics of normal cells are different from those of tumor cells, and these differences reflect the basic difference between normal and tumor cells. Normal cells divide rapidly before they grow into a monolayer, but then rapidly divide to a so-called “saturation density.” This property of normal cells can be called “density-dependent regulation of cell division.” No such phenomenon in tumor cells. Tumor cells continue to divide after growing into a monolayer, resulting in cells