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目的 探讨建立连枷胸兔模型的可行性.方法 12只新西兰大白兔麻醉后气管插管辅助呼吸,无菌手术形成连枷.运用生物信号采集系统记录胸壁反常运动信号,采集动脉血进行血气分析,心电监护记录生命体征,实验终点取肺组织进行病理学分析,分析连枷胸对实验动物呼吸功能的影响,进而验证以兔建立连枷胸模型的可行性.结果 手术顺利,无死亡.手术时间(41.42士7.08)min.气管插管时间(79.33士12.21)min.统计结果显示pH值、二氧化碳分压、剩余碱(BE)增高;血氧分压、血氧饱和度降低.病理结果显示连枷胸后长时间未得到干预治疗将对器官产生器质性变化.结论 连枷胸兔模型成功建立,可以单独研究连枷胸对机体的影响,具有可行性、安全性、可重复性、操作简便、动物来源广泛的优势,是研究连枷胸疾病过程、恢复过程、干预方案效果的基础.“,”Objective To explore the feasibility of establishing a rabbit model of flail chest.Methods Flail chest model was eatablished in 12 New Zealand white rabbits after anesthesia and sterile surgery.The paradoxical movement of chest wall was recorded by the biological signal acquisition system,arterial blood was collected for blood gas analysis,the vital signs were recorded by electrocardiogram (ECG) and the lung tissue was taken for the pathological analysis at the end of the experiment.The effect of flail chest on the respiratory function of experimental animals was analyzed to evaluate the feasibility of establishing flail chest model.Results All surgeries were successful without mortality.The operation time was 41.42±7.08 min.Duration of endotracheal intubation was 79.33± 12.21 min.Statistical results showed that the pH,partial pressure of arterial carbon dioxide (PaCO2) and base excess (BE) increased;while partial pressure of oxygen (PaO2) and oxygen saturation (SaO2) reduced.Pathological results showed that flail chest not intervented for a long period would lead to organic lesions.Conclusion The rabbit model of flail chest is feasible,safe,repeatable,easy and simple to handle.The animal is easy to access which is the foundation to study the disease process,recovery procedure and the efficacy after intervention.