Anti-inflammatory effects of Mangifera indica L.extract in a model of colitis

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:fencer_200
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM:To investigate the effect of aqueous extract from Mangifera indica L.(MIE)on dextran sulfate sodium (DSS)-induced colitis in rats.METHODS:MIE(150 mg/kg)was administered in two different protocols:(1)rectally,over 7 d at the same time as DSS administration;and(2)once daily over 14 d (by oral gavage,7 d before starting DSS,and rectally for 7 d during DSS administration).General observations of clinical signs were performed.Anti-inflammatory activity of MIE was assessed by myeloperoxidase(MPO)activity. Colonic lipid peroxidation was determined by measuring the levels of thiobarbituric acid reactive substances (TBARS).Reduced glutathione(GSH)levels,expression of inflammatory related mediators[inducible isoforms of nitric oxide synthase(iNOS)and cyclooxygenase (COX)-2,respectively]and cytokines[tumor necrosis factor(TNF)-αand TNF receptors 1 and 2]in colonic tissue were also assessed.Interleukin(IL)-6 and TNF-α serum levels were also measured. RESULTS:The results demonstrated that MIE has anti-inflammatory properties by improvement of clinical signs,reduction of ulceration and reduced MPO activity when administered before DSS.In addition,administration of MIE for 14 d resulted in an increase in GSH and reduction of TBARS levels and iNOS,COX-2, TNF-αand TNF R-2 expression in colonic tissue,and a decrease in IL-6 and TNF-αserum levels. CONCLUSION:MIE has anti-inflammatory activity in a DSS-induced rat colitis model and preventive administration(prior to DSS)seems to be a more effective protocol. AIM: To investigate the effect of aqueous extract from Mangifera indica L. (MIE) on dextran sulfate sodium (DSS) -induced colitis in rats. METHODS: MIE (150 mg / kg) was administered in two different protocols: , over 7 d at the same time as DSS administration; and (2) once daily over 14 d (by oral gavage, 7 d before starting DSS, and rectally for 7 d during DSS administration). General observations of clinical signs were performed. Anti-inflammatory activity of MIE was assessed by myeloperoxidase (MPO) activity. Colonic lipid peroxidation was determined by measuring the levels of thiobarbituric acid reactive substances (TBARS). Reduced glutathione (GSH) levels, expression of inflammatory related mediators [inducible isoforms of nitric (TNF) -alpha and TNF receptors 1 and 2] in colonic tissue were also assessed.Interleukin (IL) -6 and TNF-α serum levels were also measured. RESULTS: The results said that MIE has anti-inflammatory properties by improvement of clinical signs, reduction of ulceration and reduced MPO activity when administered before DSS. addition, administration of MIE for 14 d resulted in an increase in GSH and reduction of TBARS levels and iNOS, COX-2, TNF-α and TNF R-2 expression in colonic tissue, and a decrease in IL-6 and TNF-α serum levels. CONCLUSION: MIE has anti-inflammatory activity in a DSS-induced rat colitis model and preventive administration (prior to DSS) to be a more effective protocol.
其他文献
N-2-Thiazolylacrylamide (NTA) was polymerized by a radical route to obtain the polymer in good yield. The polymer with a pendent heterocyclic group is soluble i
麻醉药品是指对中枢神经有麻醉作用,连续使用后易产生身体依赖性、能形成瘾癖的药品。连续使用、滥用或者不合理使用,易产生身体依赖性和精神依赖性,能成瘾癖的药品。精神药
A novel platinum(IV) complex [Ph3PEt]2[PtCl6] 1 obtained from the reaction of H2PtCl6 and [Ph3PEt]I (Ph3PEt+ = ethyl-triphenylphosphenonium) has been structural
本文报告1978~1991年14年148例喉癌病人,男:女=8.9:1.近年来喉癌发病率呈上升趋势,尤其女性更为显著。发病年龄呈年轻化。城市与农村人群发病情况极相近,提示喉癌发病与空气污染无密切关系,但与吸烟密切
The results and main findings of studies reported in the literature in relation to the deposition of calcium phosphate onTi in simulated body fluids are summari
叶面施肥是补充和调节作物营养的有效措施,特别是在逆境条件下,常能发挥特殊的效果,但任何事物都是一分为二的,近几年来农民反映比较强烈的问题就是使用效果不佳,为提高叶面
正常眼和眼表疾病的泪液SIgA和IgA第一军医大学珠江医院泪液学中心周祖嫌,张汗承,汪瑞爱,朱福兴,刘金华,余明芳免疫球蛋白(Ig)A是Hereman(1959)首次从血清中分离出来的抗体。Feinstein等(1963)在人和兔的体液如初乳、唾液、
本刊将按治疗领域分期刊发新药研发信息,介绍全球主要生物医药公司目前处于研发后期(一般Ⅲ期临床后)新药的基本信息。
中共中央组织部《关于进一步做好培养选拔优秀年轻干部工作的意见》中指出 :必须进一步加紧做好培养选拔优秀年轻干部工作 ,努力造就一大批忠诚于马列主义、坚持走建设有中国
在日前召开的全国科技大会上,上海浦东新区荣获“2003~2004年度全国科技进步先进市”(按市级标准评定)光荣称号。对此殊荣,来过浦东,见证过浦东开放开发的人,一点也不感到惊