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目的观察过敏性紫癜(HSP)患儿外周血调节性和辅助性T细胞的表达水平。方法选择2016年1月-2016年12月在沈阳市儿童医院门诊就诊或住院治疗的HSP患儿34例(HSP组),另选择同期体检的健康儿童31例(对照组),比较2组外周血调节性T细胞(CD_4~+CD+25Treg和CD_4~+CD+25Foxp3+Treg)和辅助性T细胞(CD_3~+、CD_4~+、CD_8~+、CD_4~+/CD_8~+)检测结果。结果 HSP组外周血调节性T细胞CD_4~+CD+25Treg、Fox P3~+Treg及辅助性T细胞CD_3~+、CD_4~+表达水平、CD_4~+/CD_8~+比值均明显低于对照组,CD_8~+表达水平明显高于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论 HSP患儿存在明确的外周血调节性和辅助性T细胞表达异常。
Objective To observe the expression of peripheral blood regulatory T helper cells and helper T cells in children with Henoch-Schonlein purpura (HSP). Methods Thirty-four HSP patients (HSP group) and 31 healthy children (control group) were enrolled in the outpatient department of Shenyang Children’s Hospital from January 2016 to December 2016. The control group was compared with the control group The results of the detection of the blood regulatory T cells (CD_4 ~ + CD + 25Treg and CD_4 ~ + CD + 25Foxp3 + Tregs) and helper T cells (CD_3 ~ +, CD_4 ~ +, CD_8 ~ +, CD_4 ~ + / CD_8 ~ +) . Results The expressions of CD_4 ~ + CD + 25 Treg, Fox P3 ~ + Treg and T helper CD_3 ~ +, CD_4 ~ + and CD_4 ~ + / CD_8 ~ + of peripheral blood T cells in HSP group were significantly lower than those in control group , CD8 + expression levels were significantly higher than the control group, the difference was statistically significant (P <0.05 or P <0.01). Conclusion There is a clear abnormality of peripheral blood regulation and helper T cell expression in children with HSP.