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目的:探讨宫颈肿瘤筛查中液基细胞学检查(TCT)、阴道镜下活检联合应用的临床价值。方法:收集2002.12~2005.10月间张家口市及周边地区9250例已婚妇女进行常规细胞学检查,可疑宫颈病变3536例患者行液基细胞学检查,阴道镜检查及病理组织学检查。结果:液基细胞学筛查检出阳性涂片212例,占82.2%(212/258),其中不典型鳞状上皮细胞(ASCUS)占15.1%(32/212),鳞状上皮内低度病变(LAIL)占65.6%(144/212);鳞状上皮内高度病变(HSIL)占79.8%(14/16),鳞状细胞癌(SCC)占100%(22/22)。阴道镜检查阳性例数为242例,占总数的93.8%(242/258);经病理确诊为CIN及浸润癌者共197例,占TCT异常者92.9%(197/212),占阴道镜异常图象81.6%(197/242)。年龄分布上,以28~35岁发病者所占比例最大(48.5%)。结论:在宫颈病变的早期筛查中TCT联合阴道镜下活检具有重要的临床意义。
Objective: To investigate the clinical value of liquid-based cytology (TCT) and colposcopic biopsy in cervical cancer screening. Methods: A total of 9,250 married women in Zhangjiakou and surrounding areas were collected for routine cytology from 2002.12 to 2005.1035 cases of suspicious cervical lesions were examined by liquid-based cytology, colposcopy and histopathology. Results: There were 212 positive smears detected by liquid-based cytology, accounting for 82.2% (212/258), of which 15.1% (32/212) had atypical squamous epithelial cells (ASCUS) The lesions accounted for 65.6% (144/212). The lesions in squamous intraepithelial lesion (HSIL) accounted for 79.8% (14/16) and the squamous cell carcinoma (SCC) accounted for 100% (22/22). The number of colposcopy positive cases was 242, accounting for 93.8% (242/258) of the total; 197 cases were diagnosed as CIN and invasive carcinoma by pathology, accounting for 92.9% (197/212) of TCT abnormalities, accounting for colposcopy abnormalities 81.6% (197/242) of the images. Age distribution, the incidence of 28 to 35 years old the largest proportion (48.5%). Conclusion: TCT combined with colposcopic biopsy has important clinical significance in early screening of cervical lesions.