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目的 :对通心络胶囊治疗冠心病心绞痛的量效时效关系作出评价。方法 :采用随机分组对照 ,治疗组90例分为大、中、小 3个剂量组 ,在心绞痛发作时 ,分别每次给予通心络胶囊 6 ,4,2粒 ;对照组 30例给予舌下含硝酸甘油 0 .6mg。 2周后进行心绞痛、心电图的量效及时效关系评估。结果 :在量效方面 ,均以治疗组大、中剂量组为优 ;在时效方面 ,通心络胶囊起效虽慢 ,但 10min内心绞痛缓解百分率与硝酸甘油相近 (P >0 .0 5 )。结论 :4粒 /次的通心络胶囊能较快缓解冠心病心绞痛
Objective : To evaluate the dose-effect time-effect relationship of Tongxinluo Capsule in the treatment of angina pectoris of coronary heart disease. METHODS: Randomized controlled trials were used. 90 patients in the treatment group were divided into three groups: large, medium, and small. In the onset of angina pectoris, they received 6, 4, and 2 tablets of Tongxinluo capsules each time; 30 patients in the control group received sublinguals. Contains 0.6 ml of nitroglycerin. Two weeks later, angina and electrocardiogram were evaluated for dose-effect and time-effectiveness. Results: In terms of dose effect, both the treatment group and the middle-dose group were excellent; in terms of timeliness, Tongxinluo capsules had a slow onset of action, but the remission rate of angina in 10 minutes was similar to that of nitroglycerin (P > 0.05). . Conclusion : 4 capsules/time of Tongxinluo capsule can relieve coronary heart disease angina more quickly