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目的探讨血清前白蛋白(PAB)、胆碱酯酶(CHE)和腺苷脱氨酶(ADA)在评价肝硬化患者肝脏储备功能的临床价值,并筛选出反应肝脏贮备功能较好的指标。方法选取60例肝炎肝硬化患者,按照Child-Pugh评分进行分级分为A、B、C组,另取15例健康者作为对照组,均检测血清PAB、CHE、ADA与常规生化指标,其中部分晚期患者进行治疗前后的对比。结果 PAB、CHE在A、B、C组间两两比较具有明显差异性(P<0.05),部分病例治疗前后PAB、CHE相比较具有显著差异(P<0.05),而ADA、ALB无明显差异(P>0.05)。结论 PAB、CHE是反应肝硬化患者肝储备功能及其变化的敏感指标。
Objective To investigate the clinical value of serum prealbumin (PAB), cholinesterase (CHE) and adenosine deaminase (ADA) in assessing the liver function of patients with liver cirrhosis and to screen out the indexes that reflect the reserve function of the liver. Methods Sixty patients with liver cirrhosis were selected and divided into groups A, B and C according to Child-Pugh score. Another 15 healthy people were selected as control group. Serum PAB, CHE, ADA and routine biochemical indexes were detected, Comparison of patients before and after treatment. Results The PAB and CHE showed significant difference (P <0.05) between groups A, B and C, PAB and CHE in some cases before and after treatment were significantly different (P <0.05), while there was no significant difference in ADA and ALB (P> 0.05). Conclusions PAB and CHE are sensitive indicators of liver reserve function and its changes in patients with cirrhosis.