论文部分内容阅读
目的:探讨四项血清酶活性联合检测,时诊断和鉴别恶性肿瘤的应用价值。选择相关血清酶进行组合,以提高临床检测肿瘤的敏感性、有效性。方法:应用终占法检测CPDA。连续监测法检测r—CT、LDH、ALP。测定恶性肿瘤患者350例。其中肝癌132例,胃癌78例,肺癌82例,直肠癌58例。健康体检人群100例。结果:对照组各项指标与恶性肿瘤组比较,除肺癌组、直肠癌组GPDA和ALP无显著性差异P>0.05外。其余均有显著差异和有差异P<0.01和P<0.05。肝癌组单项GPDA、r—GT、LDH、ALP阳性率分别是73％、81％、42％、58％。联合检测敏感性可达95％,优于二项和单项。结论:正常细胞向恶性细胞转化常导致酶合成异常。酶学改变常出现在形态学改变之前。三项(GPDA+r—GT+ALP)酶活性联合检测可提高肝癌、胃癌诊断率和敏感性。在疗效监测方面可为临床提供有价值的资料。
Objective: To investigate the value of combined detection of four serum enzymes in diagnosis and differential diagnosis of malignant tumors. Select the combination of serum enzymes to improve the clinical detection of tumor sensitivity and effectiveness. Methods: CPDA was tested by the method of occupancy. Continuous monitoring method for detection of r-CT, LDH, ALP. 350 patients with malignant tumors were determined. 132 cases of liver cancer, 78 cases of gastric cancer, 82 cases of lung cancer, 58 cases of rectal cancer. 100 healthy people. Results: There was no significant difference in GPDA and ALP between the control group and the malignant group except lung cancer group and rectal cancer group (P> 0.05). The rest were significant differences and differences P <0.01 and P <0.05. The positive rates of single GPDA, r-GT, LDH and ALP in hepatocellular carcinoma were 73%, 81%, 42% and 58% respectively. Joint detection sensitivity up to 95%, better than two and single. Conclusion: The transformation of normal cells to malignant cells often leads to abnormal enzyme synthesis. Enzymatic changes often appear before morphological changes. The combined detection of three (GPDA + r-GT + ALP) enzyme activities can improve the diagnostic rate and sensitivity of liver cancer and gastric cancer. In the efficacy of monitoring can provide valuable information for clinical.