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目的观察奥美拉唑、阿莫西林、克拉霉素组成的三联疗法对消化性溃疡的治疗效果。方法消化性溃疡患者82例,随机平分成两组,每组41例。治疗组采用奥美拉唑20mg+阿莫西林1000mg+克拉霉素500mg三联治疗,对照组采用雷尼替丁20mg+克拉霉素500mg+阿莫西林1000mg治疗,比较治疗效果以及对Hp的根除情况。结果治疗组的有效率及Hp根除率分别为97.6%和90.2%,显著高于对照组的82.9%和75.6%,两组差异具有统计学意义(P<0.05)。结论奥美拉唑三联疗法对消化性溃疡具有良好的治疗效果,对Hp根除率较高,此方法具有临床推广使用价值。
Objective To observe the therapeutic effect of triple therapy consisting of omeprazole, amoxicillin and clarithromycin on peptic ulcer. Methods 82 cases of peptic ulcer patients were randomly divided into two groups, 41 cases in each group. The treatment group with omeprazole 20mg + amoxicillin 1000mg + clarithromycin 500mg triple therapy, the control group ranitidine 20mg + clarithromycin 500mg + amoxicillin 1000mg treatment, the treatment effect and the eradication of Hp situation. Results The effective rate and Hp eradication rate in the treatment group were 97.6% and 90.2%, respectively, which were significantly higher than those in the control group (82.9% and 75.6%, respectively). There was significant difference between the two groups (P <0.05). Conclusions Omeprazole triple therapy has a good therapeutic effect on peptic ulcer and a high eradication rate of Hp. This method has clinical value.