目的:探讨抑癌基因第10染色体同源丢失性磷酸酶—张力蛋白基因(PTEN)蛋白表达与子宫内膜癌的发生、发展的关系。方法:采用免疫组织化学S-P法检测PTEN蛋白在56例子宫内膜癌及30例正常子宫内膜组织的表达。结果:56例子宫内膜癌中PTEN蛋白表达缺失率为57.1%,明显高于正常子宫内膜中的完全表达(P<0.05)。PTEN蛋白在低分化组的表达缺失率明显高于中高分化组(P<0.05)。结论:抑癌基因PTEN蛋白表达缺失在子宫内膜癌的发生、发展、浸润等过程中有一定作用。 Objective: To investigate the relationship between PTEN protein expression and the occurrence and development of endometrial carcinoma on the 10th chromosome of tumor suppressor gene. Methods: The expression of PTEN protein in 56 cases of endometrial carcinoma and 30 cases of normal endometrium was detected by immunohistochemical S-P method. Results: The loss of PTEN protein in 56 cases of endometrial carcinoma was 57.1%, which was significantly higher than that in normal endometrium (P <0.05). The loss of PTEN protein expression in poorly differentiated group was significantly higher than that in moderately and well differentiated group (P <0.05). Conclusion: The loss of PTEN protein may play a role in the occurrence, development and infiltration of endometrial carcinoma.