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目的:研究芪松调律方治疗室性早搏伴窦缓的临床疗效及安全性。方法:采用随机、双盲、安慰剂平行对照的方法,100例受试者随机分为试验组和对照组,试验组服用芪松调律方治疗,1剂/日,对照组服用安慰剂,1剂/日,疗程均为12周。观察治疗12周2组室性早搏总数、平均心率及临床症状计分与基线比较的变化值。结果:对室性早搏疗效,对照组显效1例,有效6例,无效41例,试验组显效13例,有效25例,无效8例。临床症状疗效,对照组临床痊愈0例,显效2例,有效6例,无效40;试验组临床痊愈8例,显效12例,有效20例,无效6例。早搏次数疗效,对照组治疗后为(8.4±8.2)千次/24h,试验组治疗后为(4.6±5.0)千次/24h;平均心率疗效,对照组治疗后为(49.5±15.0)次/分,试验组治疗后为(55.7±12.7)次/分;临床症状积分疗效,对照组治疗后为(17.5±5.0)分,试验组治疗后为(5.7±2.7)分。经统计,以上指标2组比较均有统计学意义。结论:芪松调律方治疗室性早搏伴窦缓安全有效。
Objective: To study the clinical curative effect and safety of Qisong Tiaochuan Recipe in the treatment of ventricular premature beats with sinus slowness. Methods: A randomized, double-blind, placebo-controlled parallel method was used. 100 subjects were randomly divided into experimental group and control group. The experimental group was treated with Qisong Tiaogan Recipe, one dose daily, the control group was given placebo, 1 dose / day, treatment are 12 weeks. The changes of the total number of premature ventricular contractions, the average heart rate and clinical symptom scores in two groups at 12 weeks of treatment were compared with the baseline values. Results: The efficacy of ventricular premature beats in the control group, 1 case markedly effective in 6 cases, 41 cases were ineffective, the experimental group markedly effective in 13 cases, effective in 25 cases, 8 cases. In the control group, 0 cases were clinically cured, 2 cases markedly effective, 6 effective and 40 ineffective. The experimental group was clinically cured in 8 cases, markedly effective in 12 cases, effective in 20 cases and ineffective in 6 cases. (8.4 ± 8.2) times per 24 hours after treatment in the control group and (4.6 ± 5.0) times per 24 hours after the treatment in the control group. The average heart rate after treatment in the control group was (49.5 ± 15.0) times / (55.7 ± 12.7) times per minute after treatment in the experimental group. The clinical symptom scores were (17.5 ± 5.0) points in the control group and (5.7 ± 2.7) points in the experimental group after treatment. After statistics, the above two indicators were statistically significant. Conclusion: Qigong Tonic prescription for the treatment of ventricular premature beats with sinus slowly and safely.