目的 :研究可乐宁与可乐宁 +丁丙诺啡治疗海洛因成瘾者的疗效比较。方法 :6 0例海洛因成瘾者随机分成两组。单盲法 (被观察者 )分别给予可乐宁加安慰剂注射用水及可乐宁加丁丙诺啡注射 ,10天为一疗程。用药前后分别对戒断症状评定并隔日取尿作尿吗啡定性测验。结果 :可乐宁合并丁丙诺啡能够有效地控制海洛因的戒断症状 ,总体疗效优于单用可乐宁且副反应小 ,病人依从性佳。结论 :可乐宁合并丁丙诺啡是一种安全、有效的脱瘾治疗方案 ,临床疗效优于单用可乐定脱瘾治疗 Objective: To compare the curative effect between clonidine and clonidine + buprenorphine in the treatment of heroin addicts. Methods: Sixty heroin addicts were randomly divided into two groups. The single-blind (observed) patients were given Clonidine plus placebo for injection and Colein plus buprenorphine for 10 days, respectively. Before and after treatment were assessed on withdrawal symptoms and urine taken the next day for urine morphine qualitative test. Results: Coleraine combined buprenorphine can effectively control heroin withdrawal symptoms, the overall effect is better than the single with clonidine and side effects, patient compliance. Conclusion: Coleraine combined with buprenorphine is a safe and effective drug treatment program, the clinical curative effect is superior to that of clonidine alone