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目的 :探讨脆性组氨三联体 (FHIT)蛋白在胃癌中的表达状况及其预后价值。方法 :应用免疫组化技术 (S P)法检测FHIT在 78例胃癌中的表达。结果 :78例胃癌中 44例显示FHIT蛋白缺失。FHIT缺失与肿瘤的大小、部位、浸润深度、分级、分期、淋巴结转移与否无相关性。结论 :FHIT蛋白缺失在胃癌组织中是频发事件。FHIT蛋白在胃癌中缺乏及其与预后的关系 ,尚须大量研究阐明。
Objective: To investigate the expression of FHIT protein in gastric carcinoma and its prognostic value. Methods: The expression of FHIT in 78 cases of gastric cancer was detected by immunohistochemistry (S P) method. Results: 44 cases of 78 cases of gastric cancer showed FHIT protein deletion. FHIT deletion and tumor size, location, depth of invasion, grading, staging, lymph node metastasis or not. Conclusion: The deletion of FHIT protein is a frequent event in gastric cancer. The lack of FHIT protein in gastric cancer and its relationship with the prognosis, still need a lot of research to clarify.