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癌症恶病质(Cancer Cachexia,C-C)是伴随肿瘤患者病情进展,尤其是晚期肿瘤患者出现的一种综合征,其以蛋白质、脂类、糖类代谢异常为特点,其临床表现为食欲不振、极度消瘦、贫血、无力和衰竭等,癌症患者的病死率因此可上升近50％。人们对此虽然研究已久,但至今尚无一明确的解释。尽管厌食现象往往伴随癌症恶病质的产生过程,但仅以食物摄取下降尚不能完全解释其所有现象,同时临床上营养支持治疗亦未取得明显成功,因而对于癌症恶病质形成机制的探讨,可为进一步的临床治疗提供思路和方法,本文参考相关文献,拟以细胞因子、循环激素在癌症恶病质形成过程中的作用综述分析如下。
Cancer Cachexia (CC) is a syndrome associated with the progress of patients with cancer, especially in advanced cancer patients. It is characterized by abnormal metabolism of proteins, lipids, and carbohydrates. Its clinical manifestations are loss of appetite and extreme weight loss. With anaemia, asthenia, and failure, cancer mortality can rise by nearly 50%. Although people have studied this for a long time, there is no clear explanation yet. Although anorexia is often associated with the development of cancer cachexia, the decline in food intake alone does not completely explain all of its phenomena. At the same time, clinical nutrition support and treatment have not achieved significant success. Therefore, the discussion on the mechanism of cancer cachexia formation can be further studied. Clinical treatment provides ideas and methods. This article refers to the relevant literature. It is intended to review and analyze the role of cytokines and circulating hormones in the formation of cancer cachexia as follows.