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据美国 Science,2002,296:1860报道,斯坦福大学的一个科研小组通过实验说明,中枢神经系统在发育过程中丧失再生能力,这部分归因于神经元细胞内在的不可逆变化。中枢神经的神经元在发育早期即失去了再生轴突的能力,而人们一直不清楚其原因。一种主流观点认为,是由于成年中枢神经的胶质细胞分泌了化学信号分子,强烈抑制神经元轴突的生长。那么,是否克服了这些抑制因子就足以恢复神经元快速生长的能力,抑或成年神经元细胞已经发生了内在的变化? 为此,美国斯坦福大学的戈德堡(J.
According to the report of Science, 2002, 296: 1860, a research group at Stanford University shows through experimentation that the central nervous system loses its ability to regenerate during development, due in part to the inherent irreversible changes in neuronal cells. Neurons in the central nervous system lose their ability to regenerate axons in the early stages of development, and people are not sure why. A mainstream view is that as the adult CNG glial cells secrete chemical signal molecules, strongly inhibit neuronal axon growth. So, whether overcoming these inhibitors is sufficient to restore the ability of neurons to grow rapidly, or whether adult neuronal cells have undergone intrinsic changes? To this end, Goldberg of the U.S. Stanford University (J.