Two new species of Curcuma, C. sattayasaii A. Chaveerach & R. Sudmoon and C. zedoaroides A. Chaveerach & T. Tanee with rhizomes traditionally used for many decades as cobra-bite antidotes are described and illustrated. Curcuma sattayasaii is similar to C. longa L., but differs in rhizome horizontally branching on ground;coma bracts pinkish-white or pinkish-pale green;corolla pale yellow with orange tip;labellum pale orange with an orange central band;anther crest very short, broadly ovate, wider than long. Curcuma zedoaroides is similar to C. zedoaria (Christm.) Roscoe, but differs in rhizome branching pattern;the protruding secondary rhizomes curved down;blades oblong to oblong-lanceolate;peduncle glabrous;fertile and coma bracts glabrous;corolla lobes pale yellow to white, lateral lobe ovate, dorsal lobe broadly ovate. The new taxa have been found in a village of Khon Kaen Province, Northeastern Thailand.