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目的探讨Rosai-Dorfman病(RDD)的临床表现、诊断、组织特征及治疗。方法研究RDD1例,结合文献回顾分析。结果RDD1例,病理见大量淋巴细胞、浆细胞及组织细胞,并有吞噬淋巴细胞现象,免疫组化S-100强阳性。本病临床表现多样,易误诊。结论RDD是良性的组织细胞增生性疾病,预后主要取决于患者的免疫功能状态、淋巴结受累数目及结外器官受累部位,诊断主要依靠病理及免疫组化,治疗上以综合治疗为主,治疗后应随访。
Objective To investigate the clinical manifestations, diagnosis, histological features and treatment of Rosai-Dorfman disease (RDD). Methods RDD1 cases, combined with literature review analysis. Results RDD1 cases, pathological see a large number of lymphocytes, plasma cells and tissue cells, and phagocytosis of lymphocytes, strong immunohistochemical S-100 positive. The clinical manifestations of the disease is diverse, easily misdiagnosed. Conclusions RDD is a benign histiocytic disease. The prognosis mainly depends on the immunological status of patients, the number of lymph nodes involved and the location of extranodal organ involvement. The diagnosis mainly depends on the pathology and immunohistochemistry. The treatment is mainly based on comprehensive treatment. After treatment Should be followed up.