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前列腺癌是男性泌尿生殖系最常见的恶性肿瘤之一,日益成为人类男性健康的威胁。microRNA由于其特异性的转录后调节作用,在生命进化、发育以及肿瘤的发生、进展中都发挥着重要作用。研究表明,前列腺癌中异常表达的microRNA在前列腺癌的发生和发展中起到了重要作用。本文就microRNA在前列腺癌中的表达谱改变、与去势抵抗性前列腺癌的进展和化疗药耐药的关系以及临床应用等方面作一综述。
Prostate cancer is one of the most common malignant tumors of the male genitourinary tract and is increasingly becoming a threat to the health of human men. Because of its specific post-transcriptional regulation, microRNA plays an important role in the evolution and development of life and in the development and progression of tumors. Studies have shown that abnormally expressed microRNAs in prostate cancer play an important role in the development and progression of prostate cancer. This review summarizes the changes of microRNA expression profile in prostate cancer, its relationship with the development of anti-prostate cancer and chemoresistance, and its clinical application.