目的探讨阴茎原发恶性黑色素瘤的临床症状、病理特点及诊断治疗。方法对4例阴茎原发恶性黑色素瘤的病理和临床资料进行回顾性分析。结果4例均行阴茎部分切除,双侧腹股沟淋巴结清扫术。术后4例均行化疗,其中2例化疗联合生物学治疗。结论阴茎原发恶性黑色素瘤临床罕见,确诊依靠病理,手术为主要治疗手段,术后行化疗联合生物学治疗可提高生存期,但因其恶性程度高,预后不佳。 Objective To investigate the clinical symptoms, pathological features and diagnosis and treatment of primary malignant melanoma of the penis. Methods The pathology and clinical data of 4 primary malignant melanoma of the penis were retrospectively analyzed. Results All the patients underwent penile partial resection and bilateral inguinal lymphadenectomy. Four patients underwent postoperative chemotherapy, of which two chemotherapy combined with biological therapy. Conclusions Primary malignant melanoma of the penis is clinically rare and its diagnosis depends on pathology and operation as the main treatment. Postoperative chemotherapy combined with biological therapy can improve survival, but its prognosis is poor because of its high malignancy.