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目的:探讨鼻用糖皮质激素对儿童阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的治疗效果。方法:符合条件的OSAHS患儿96例,根据多导睡眠监测结果分成轻度OSAHS组32例,中重度OSAHS组64例。所有患儿经鼻用糖皮质激素喷鼻,连续用药1月以上,1月后进行多导睡眠监测复查。结果:轻度OSAHS组睡眠呼吸监测呼吸暂停低通气指数(AHI)经鼻用糖皮质激素喷鼻剂治疗1月后由治疗前的8.43±1.32降低为治疗后的3.23±1.32,差异有统计学意义(P<0.05);中重度OSAHS组治疗前AHI为26.32±8.56,治疗后为17.32±4.22,差异无统计学意义(P>0.05)。结论:鼻用糖皮质激素对儿童OSAHS治疗有一定疗效,尤其对于轻度OSAHS患儿,对于中重度OSAHS患儿疗效不显著。
Objective: To investigate the therapeutic effect of nasal glucocorticoid on obstructive sleep apnea hypopnea syndrome (OSAHS) in children. Methods: A total of 96 eligible OSAHS patients were divided into two groups: mild OSAHS group (n = 32) and moderate or severe OSAHS group (n = 64) based on polysomnography. All children nasal corticosteroid nasal spray, continuous medication for more than 1 month, 1 month after polysomnography monitoring review. Results: The sleep apnea hypopnea index (AHI) of mild OSAHS group was decreased from 8.43 ± 1.32 before treatment to 3.23 ± 1.32 after treatment with nasal glucocorticoid nasal spray for one month, the difference was statistically significant (P <0.05). Before the treatment, the AHI in the moderate and severe OSAHS group was 26.32 ± 8.56, and it was 17.32 ± 4.22 after the treatment. The difference was not statistically significant (P> 0.05). Conclusion: Nasal glucocorticoids have some effect on the treatment of OSAHS in children. Especially for children with mild OSAHS, the curative effect is not significant for children with moderate-severe OSAHS.