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目的探讨原发性小肝癌术后早期复发转移的危险因素,为预测和预防小肝癌术后早期复发转移提供理论依据。方法回顾性分析2008-2011年行根治性切除的单发且直径≤5cm的小肝癌患者中术后早期复发转移和晚期复发转移的临床病理特征,用单因素和多因素分析小肝癌早期复发转移的危险因素。结果单因素分析显示小肝癌术后早期复发组和晚期复发组间肿瘤有无包膜(P=0.027)、术后TBIL峰值(P=0.034)、镜下脉管癌栓(P=0.036)有显著性差异;多因素分析提示肿瘤有无包膜是小肝癌术后早期复发的独立危险因素。结论小肝癌复发时间可能与肿瘤有无包膜,术后TBIL峰值和镜下脉管癌栓等因素有关,而肿瘤有无包膜是小肝癌术后早期复发的独立危险因素,需加强此类患的者术后监测,并提前进行干预。
Objective To investigate the risk factors of early postoperative recurrence and metastasis of primary small hepatocellular carcinoma and provide theoretical basis for predicting and preventing the early postoperative recurrence and metastasis of small hepatocellular carcinoma. Methods The clinicopathological features of early postoperative recurrence and metastasis and late recurrence and metastasis in patients with small hepatocellular carcinoma who were excised singly and with a diameter less than 5cm from 2008 to 2011 were analyzed retrospectively. The early recurrence and metastasis of small hepatocellular carcinoma was analyzed by univariate and multivariate analysis Risk factors. Results Univariate analysis showed that there was no tumor (P = 0.027), postoperative TBIL peak (P = 0.034), microscopic vascular thrombus (P = 0.036) in small hepatocellular carcinoma after operation Significant differences; Multivariate analysis showed that the presence of tumor capsule is an independent risk factor for early recurrence of small hepatocellular carcinoma. Conclusions The recurrence time of small hepatocellular carcinoma may be related to the presence or absence of tumor capsule, postoperative TBIL peak and microscopic vascular thrombosis and other factors. The presence or absence of tumor capsule is an independent risk factor for early postoperative recurrence of small hepatocellular carcinoma. Patients suffering from postoperative monitoring and intervention in advance.