低氧性肺动脉高压是临床众多疾病发生发展过程中的重要病理生理环节,低氧性肺血管结构重建作为慢性低氧性肺动脉高压形成中重要的病理生理机制,近年来受到越来越多的重视。然而,低氧性肺血管结构重建的发生机制尚未完全清楚。一氧化氮(NO)是一种新型的细胞信使分子,由L-精氨酸(L-Arg)和氧分子在一氧化氮合酶(NOS)及其辅因子的作用下产生,近年来人们对其在调节低氧性肺血管结构重建 Hypoxic pulmonary hypertension is an important pathophysiological link in the development and progression of many clinical diseases. Hypoxic pulmonary vascular remodeling, as an important pathophysiological mechanism in the formation of chronic hypoxic pulmonary hypertension, has received more and more attention in recent years . However, the pathogenesis of hypoxic pulmonary vascular remodeling is not fully understood. Nitric oxide (NO) is a novel cell messenger molecule produced by L-arginine (L-Arg) and oxygen molecules under the action of nitric oxide synthase (NOS) and its cofactors. In recent years, Its regulation of hypoxic pulmonary vascular remodeling