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本实验应用免疫组织化学法,研究人肝细胞生长因子(HGF)在6~7个月胎儿各脏器的分布情况。结果显示了HGF大量分布于胎儿的肝脏,其中以较小的、核深染的肝细胞为主。在肾脏,HGF呈中等量分布。在胃、十二指肠、胰腺、肾上腺等HGF只有少量的分布。结果提示了在胎儿发育6~7个月时,HGF主要由胎儿肝脏的较小的肝细胞产生,对胎儿肝脏、肾脏的生长发育有相对的器官特异性。
In this study, immunohistochemistry was used to study the distribution of human hepatocyte growth factor (HGF) in various organs of the fetus from 6 to 7 months. The results showed that a large number of HGF distributed in the liver of the fetus, with smaller, nuclear stained liver cells. In the kidney, HGF was moderately distributed. HGF in the stomach, duodenum, pancreas, adrenal gland only a small amount of distribution. The results suggest that at 6-7 months of fetal development, HGF is mainly produced by the smaller hepatocytes of the fetal liver and has relatively organ-specific effects on the growth and development of the fetal liver and kidney.