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Objective: To evaluate the clinical application of proton magnetic resonance spectroscopy (1HMRS) in patients with radiotherapy treated intracranial tumors. Methods: Forty patients with intracranial tumors underwent multivoxel 1HMRS examination before and after radiotherapy. The concentrations of N-acetyl aspartate (NAA), choline (Cho) and creatine (Cr)were obtained both in the tumors and the contralateral normal brain regions. The ratios of NAA/Cr, Cho/Cr and Cho/NAA were calculated at the same time and follow-up one year. Results: (1) After radiotherapy, tumors inhibited by radiation had decreased Cho, NAA and Cr on proton MRS. Some cases showed necrotic wave. (2) During the one year follow-up, local tumor recurred in 8 cases and their Cho and Cho/NAA increased high again. Other cases without recurrence, 1HMRS showed no change. Conclusion: Multivoxel proton MR spectroscopy is available for study of tumor metabolites after radiotherapy and it is a valuable method in the evaluation of radiotherapy treated tumors.