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[目的]探讨人乳头状瘤病毒(HPV)在新疆哈萨克族食管癌、癌旁组织及正常食管黏膜组织中的感染情况及感染后意义。[方法]采用聚合酶链反应(PCR)技术检测80例食管鳞癌和对应80例癌旁正常鳞状上皮组织及80例正常食管黏膜组织中HPV感染情况,采用χ2检验分析HPV感染与食管癌发生发展的相关性。[结果]80例食管癌组织、癌旁组织及正常食管黏膜组织中HPV感染阳性率分别为42.5%、25%、13.75%。统计学结果显示食管癌组与癌旁正常鳞状上皮组及正常食管黏膜组HPV感染,差异有统计学意义(χ2=17.006,P﹤0.05)。[结论]新疆哈萨克族食管癌组织中存在HPV感染,HPV感染可能与食管癌的发生、发展有关。
[Objective] To investigate the infection status of human papilloma virus (HPV) in esophageal carcinoma, adjacent non-cancerous tissues and normal esophageal mucosa in Kazak of Xinjiang and its significance after infection. [Method] Polymerase chain reaction (PCR) was used to detect HPV infection in 80 cases of esophageal squamous cell carcinoma and 80 cases of adjacent normal squamous epithelium tissues and 80 cases of normal esophageal mucosa tissues. Χ2 test was used to analyze the relationship between HPV infection and esophageal cancer Relevance for development. [Results] The positive rates of HPV infection in 80 cases of esophageal cancer tissue, paracancerous tissue and normal esophageal mucosa were 42.5%, 25% and 13.75% respectively. Statistical analysis showed that there was significant difference in HPV infection between esophageal cancer group and adjacent normal squamous epithelium group and normal esophageal mucosa group (χ2 = 17.006, P <0.05). [Conclusion] There is HPV infection in esophageal carcinoma of Kazak in Xinjiang, which may be related to the occurrence and development of esophageal cancer.