论文部分内容阅读
我院临床上使用止血敏注射液作混合静脉滴注时,多次发现有不明原因的变色反应。为探讨变色原因,曾进行了多方面的实验研究。在实验中,发现止血敏注射液与等渗氯化钠注射液混合后 pH 为5.5,没有颜色变化。然而当加入不同浓度的 N/10碳酸氢钠时,pH 逐渐升高,开始有变色反应,变化点的 pH 值为6.7。实验表明:每1ml 溶液中含有2mg 止血敏与10ppm的微量碱性物混合后,即产生不同程度的变色反应。此种混合液,用72型分光光度计在500nm波长处测定光密度证实:pH 越高,放置时间越长,颜色就越深,光密度也越大。由此表明:pH 的变化是止血敏注射液在配伍中变色的主要原因。
Clinical use of bleeding in our hospital for intravenous infusion mixture, many times found that there are unknown reasons for the color reaction. To explore the causes of discoloration, a number of experimental studies have been conducted. In the experiment, it was found that the bleeding Zhimin injection and isotonic sodium chloride injection pH 5.5, no color change. However, when different concentrations of N / 10 sodium bicarbonate were added, the pH gradually increased and discoloration reaction started. The pH of the changing point was 6.7. Experiments show that: 1ml solution containing 2mg hemostatic sensitivity and 10ppm trace alkaline mixture, which have different degrees of color reaction. The determination of the optical density of this mixed solution at 500 nm using a Model 72 spectrophotometer confirmed that the higher the pH the longer the setting, the darker the color and the higher the optical density. This shows that: changes in pH is the main reason for the bleeding Zhimin injection compatibility.