1992年由美国胸科医师学会/重症医学学会联席会议委员会提出全身炎性反应综合征(SIRS)的概念[1]。SIRS是严重损伤后,机体修复和生存而出现的一种过度应激反应;核转录因子(NF)-κB是炎症信号的最终汇合点。NF-κB的过度活化是SIRS发生发展的重要机制,调控NF-κB成为治疗SIRS的新 The concept of systemic inflammatory response syndrome (SIRS) was proposed by the Joint Meeting of the American College of Chest Physicians / Critical Care Medicine in 1992 [1]. SIRS is a kind of over-stress reaction after severe injury and body repair and survival; nuclear transcription factor (NF) -κB is the final convergence point of inflammatory signals. Overexpression of NF-κB is an important mechanism for the development of SIRS. Regulating NF-κB as a new treatment of SIRS