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临床医学的基础研究发现,动脉粥样硬化斑块的易损性与其生理特征密切相关,主要包括:大的脂质核、薄的纤维帽、斑块负荷等。临床现有的血管内超声(Intravascular Ultrasound,IVUS),能够对血管和斑块的整体结构进行成像;而血管内光学相干层析(Intravascular Optical Coherence Tomography,IVOCT)可以较好的分辨薄的纤维帽。但两者均只能获取血管及斑块的结构信息,无法获得斑块的组分、炎症等功能特征信息。而光声技术可以利用不同成分对光
Basic research in clinical medicine found that the vulnerability of atherosclerotic plaque is closely related to its physiological characteristics, including: large lipid core, thin fibrous cap, plaque load and so on. Intravenous Ultrasound (IVUS), which is clinically available, can image the entire structure of blood vessels and plaques. Intravascular Optical Coherence Tomography (IVOCT) can distinguish thin fibrous caps . However, both of them can only obtain the structure information of blood vessel and plaque, and can not obtain the feature information of plaque components and inflammation. The photoacoustic technology can use different components of the light