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目的： 观察活血通脉片（ＨＸＴＭＴ）对实验犬心肌缺血、心肌梗塞血清肌酸磷酸激酶（ＣＰＫ）， 血清乳酸脱氢酶（ＬＤＨ）及血浆内皮素（ＥＴ）的影响． 方法： 采用结扎冠脉，造成犬急性心肌缺血模型，经十二指肠灌入实验药物，经颈外静脉插管至冠状静脉窦，测定结扎冠脉药前及药后不同实验时间点的ＣＰＫ， ＬＤＨ， ＥＴ． 结果： 实验结果表明，与对照组比较，活血通脉片能显著抑制心肌缺血及心肌梗塞引起的ＣＰＫ活性升高（Ｐ＜ ０．０５，Ｐ＜ ０．０１），能降低ＥＴ含量（Ｐ＜ ０．０５），并对ＬＤＨ有抑制作用（Ｐ＜ ０．０５）． 结论： 活血通脉片对实验性急性心肌缺血及急性心肌梗塞ＣＰＫ， ＬＤＨ及ＥＴ有抑制作用，为冠心病的治疗及预防提供了实验依据．
Objective: To observe the effect of Huoxue Tongmai Tablet (HXTMT) on serum creatine phosphokinase (CPK), serum lactate dehydrogenase (LDH) and plasma endothelin (ET) in experimental dogs with myocardial ischemia and myocardial infarction. METHODS: The model of acute myocardial ischemia in dogs was induced by ligation of coronary artery. The experimental drugs were injected into the duodenum and the external jugular vein was cannulated to the coronary sinus to determine the different experimental time points before and after coronary artery ligation. CPK, LDH, ET. Results: The experimental results showed that compared with the control group, Huoxue Tongmai Tablet could significantly inhibit the increase of CPK activity caused by myocardial ischemia and myocardial infarction (P<0.05, P<0.01) and reduce the ET content (P < 0.05), and have an inhibitory effect on LDH (P < 0.05). Conclusion: Huoxue Tongmai tablets can inhibit the CPK, LDH and ET of experimental acute myocardial infarction and acute myocardial infarction, and provide experimental basis for the treatment and prevention of coronary heart disease.