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目的探讨Ang-1和Ang-2及其受体Tie-2在鼻咽癌(nasopharyngeal carcinoma,NPC)患者血循环中的表达及其临床意义。方法应用酶联免疫吸附试验检测2009年5月至2010年6月本科收治的低分化鳞状细胞癌患者68例,其中男性52例,女性16例,中位年龄42(19～65)岁(初治32例,完全缓解20例,复发16例)及20例健康对照者血清Ang-1和Ang-2及其受体Tie-2水平。结果初治组和复发组NPC患者血清Ang-1和Ang-2及其受体Tie-2的水平均高于完全缓解组及健康对照组(P<0.01),而这些分子的含量在完全缓解组和健康对照组比较无明显差异(P>0.05)。Ang-2及Tie-2的水平在NPC患者不同T分期、临床分期比较有差异(P<0.05),并随着NPC进展呈上升趋势;Ang-1水平在不同T分期、临床分期比较差异不显著(P>0.05);Ang-2水平在不同N分期比较有差异(P<0.05)。转移NPC患者血清Ang-2及其受体Tie-2水平明显高于无转移组(P<0.01)。Ⅰ+Ⅱ期NPC患者血清Ang-1/Ang-2比值高于Ⅲ+IVa期(P<0.01)。结论 Ang-1和Ang-2及其受体Tie-2在鼻咽癌的发生、发展过程中起重要作用,并与肿瘤的侵袭转移有密切关系。
Objective To investigate the expression of Ang-1, Ang-2 and its receptor Tie-2 in the blood circulation of patients with nasopharyngeal carcinoma (NPC) and its clinical significance. Methods 68 patients with poorly differentiated squamous cell carcinoma admitted to our hospital from May 2009 to June 2010 were enrolled in the study. Among them, 52 were male and 16 were female, with a median age of 42 (19-65) years 32 cases were initially treated, 20 cases were completely relieved, 16 cases were relapsed) and 20 cases of healthy control. The levels of Ang-1, Ang-2 and their receptor Tie-2 were detected. Results The serum levels of Ang-1, Ang-2 and its receptor Tie-2 in patients with primary and recurrent NPC were significantly higher than those in patients with complete remission and healthy controls (P <0.01), and the levels of these molecules were completely relieved Group and healthy control group no significant difference (P> 0.05). The levels of Ang-2 and Tie-2 in NPC patients with different T stages and clinical stages were significantly different (P <0.05), and with the progression of NPC, the levels of Ang-2 and Tie-2 were higher in different T stages (P> 0.05). There was significant difference in Ang-2 levels between different N stages (P <0.05). The level of serum Ang-2 and its receptor Tie-2 in patients with NPC metastasis was significantly higher than that in patients without metastasis (P <0.01). The serum Ang-1 / Ang-2 ratio in stage Ⅰ + Ⅱ NPC was higher than that in stage Ⅲ + IVa (P <0.01). Conclusions Ang-1, Ang-2 and their receptor Tie-2 play an important role in the occurrence and development of nasopharyngeal carcinoma and are closely related to the invasion and metastasis of the tumor.