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目的探讨常州市耐多药肺结核(Multidrug-resistant tuberculosis,MDR-TB)流行特征,为防治肺结核传播提供参考。方法收集结核病专报系统2012年1月1日至2014年12月31日常州市涂阳肺结核患者作为筛查对象,分析MDR-TB发病情况与流行特征。结果共筛查肺结核涂阳患者1 368例,其中确诊为MDR-TB的62例,耐药率为4.53%。男性MDR-TB发病率高于女性(P<0.05),20~、40~岁年龄组患者MDR-TB发病率高于0~、60~岁年龄组(P<0.05)。MDR-TB患者中复治占66.13%,初始占33.87%(P<0.05)。7类不同涂阳患者类型中以复治失败患者耐多药率最高(25.00%)。结论常州市MDR-TB发病水平略低于全国平均水平,与性别、年龄、不同治疗分类等有关。
Objective To investigate the epidemiological characteristics of multidrug-resistant tuberculosis (MDR-TB) in Changzhou and provide a reference for the prevention and treatment of tuberculosis. Methods Collection of tuberculosis reporting system From January 1, 2012 to December 31, 2014, smear-positive pulmonary tuberculosis patients in Changzhou City were screened for the incidence and prevalence of MDR-TB. Results A total of 1 368 cases of smear positive pulmonary tuberculosis were screened, of which 62 cases were diagnosed as MDR-TB. The resistance rate was 4.53%. The incidence of MDR-TB in males was higher than that in females (P <0.05). The incidence of MDR-TB in 20 ~ 40 years old group was higher than that in 0 ~ 60 years old group (P <0.05). In MDR-TB patients, retreatment accounted for 66.13%, initially accounting for 33.87% (P <0.05). Among the seven types of smear-positive patients, the multidrug resistance rate was the highest in patients who failed retreatment (25.00%). Conclusions The morbidity of MDR-TB in Changzhou City is slightly lower than the national average, which is related to sex, age, different treatment classification and so on.