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目的：探讨涎腺肿瘤细胞的形态分化、组织发生及其异质性。方法：采用光镜、免疫组化技术对８例腺淋巴瘤、３例嗜酸性腺瘤、１２例多形性腺瘤及２例上皮－肌上皮癌进行研究，同时观察了５６例胚胎颌下腺组织作为对照。结果：多形性腺癌中导管样结构系肿瘤性闰管结构和肿瘤性分泌管结构；腺淋巴瘤和嗜酸性腺瘤中导管结构系肿瘤性分泌管结构；上皮－肌上皮癌中导管结构系肿瘤性闰管结构；涎腺肿瘤组织结构及抗原表达复杂多样，与人胚涎腺发生过程中结构及抗原表达有相似之处。结论：涎腺肿瘤的复杂性系致瘤因素作用于不同干细胞或同一干细胞不同分化阶段所致。
Objective: To investigate the morphological differentiation, histogenesis and heterogeneity of salivary gland tumor cells. Methods: Eight cases of adenolymphoma, 3 cases of eosinophil adenoma, 12 cases of pleomorphic adenoma and 2 cases of epithelial-myoepithelial carcinoma were studied by light microscopy and immunohistochemistry. At the same time, 56 cases of embryonic submandibular gland tissue were observed. Control. RESULTS: The ductal structure of the pleomorphic adenocarcinoma was a tumoral fistula structure and a tumor-secreting ductal structure; the ductal structure of the adenolymphoma and eosinophil adenoma was a tumor-secreting ductal structure; the ductal architecture of the epithelial-muscular epithelial carcinoma. Tumorous fistula structure; salivary gland tumor tissue structure and antigen expression is complex and diverse, similar to the structure and antigen expression during the development of human embryonic parotid gland. Conclusion: The complexity of salivary gland tumors is due to the oncogenic factors acting on different stem cells or different differentiation phases of the same stem cells.